Composition and usage of mexedrone


Mexedrone is a stimulant research chemical which belongs to the cathinone class. It can vary the reuptake of dopamine, serotonin, or norepinephrine to cause euphoria. Mexedrone is much more like Mephedrone in regards to its functioning. It is termed as designer research chemical which is legal globally. Mexedrone which is also called as 3-methoxy-2-(methylamino)-1-(p-tolyl) propane-1-one is a well-reputed drug.


• Chemistry of Mexedrone


Mexedrone is a synthetic research chemical that belongs to the cathinone family. Cathinones have much more similarity with amphetamines structurally. The core of structure Mexedrone is consist of a phenyl ring with attached amino (NH2) group via an ethyl chain which contains methyl with substituted Rα. The core feature of Mexedrone is the phenethylamine structure. Basically, cathinones and Amphetamines are alpha-methylated phenethylamines. Cathinones have attached ketone group at the place of R1.


• Pharmacology of mexedrone:


Mexedrone is very weak research chemical of serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) which has IC50 values of 6844 nM,5289 nM, 8869 nM. Also, it is a weak serotonin releasing agent (SRA) with an EC50 value of 2525 nM.


• Subjective effects


Numerous subjective effects of usage of Mexedrone are determined on the basis of subjective effects index and personal experiences of PsychonautWiki contributors. So, its effects are compared with a grain of salt because it rarely affects the body. Although if Mexedrone is taken in heavy amount its effects will be enhanced. Similarly, if this research chemical is taken in form of higher doses it can cause serious illness even death.


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