Etizolam

Product Code: Etizolam
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Etizolam (also known by the trade names Etilaam, Etizest, among many others) is a synthetic, fast-acting depressant substance of the thienodiazepine chemical class that produces benzodiazepine-like anxiety suppressing, disinhibiting, muscle relaxing, sedating, and memory suppressing effects when administered. Etizolam is commonly administered orally and sublingually due to the efficiency of these routes.

Etizolam is not commonly prescribed and is not recognized as a controlled substance in many parts of the world, which has led to its rise as a popular research chemical substitute for pharmaceutical benzodiazepines, typically those that are sought after for their recreational effects. It is commonly found in pellet or pill form, laid on a blotter sheet, or as a powder.

Anecdotal reports suggest that in terms of its relative potency, 1 mg of etizolam is approximately equivalent to 0.5 mg of alprazolam (common trade name "Xanax"), 0.5 mg of clonazepam (common trade name "Klonopin"), or 10 mg of diazepam (common trade name "Valium"). It is often compared to a less potent and sedating version of alprazolam in terms of the speed of its onset, total duration, and recreational potential.

Users should note that that as with benzodiazepines, the sudden discontinuation of thienodiazepines can be potentially dangerous or even life-threatening for individuals who have been using the substance regularly for extended periods of time, as it can result in fatal seizures. As a result, individuals who find themselves physically dependent on this substance are highly advised to taper their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping their intake abruptly.

Due to the high dependence-forming and addiction potential that this substance shares with members of the closely related benzodiazepine class, as well as its alcohol-like ability to induce dangerous disinhibitory black-out states, it is highly advised to use proper harm reduction practices if choosing to use this substance.
Chemistry

Etizolam is a structural relative of benzodiazepines, whereby the benzene ring has been replaced by a thiophene ring, classifying it as a thienodiazepine. Thiophene is a five membered aromatic ring with one sulfur atom. Etizolam contains a thiophene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. This forms the thienodiazepine core of etizolam. An ethyl chain is bound to this bicyclic structure at R7. Additionally, a R2' chlorine-substituted phenyl ring is bound to this structure at R5.

Etizolam also contains a methylated triazole ring fused to and incorporating R1 and R2 of its diazepine ring. Etizolam shares this fused triazole ring substitution with certain benzodiazepine drugs, called triazolobenzodiazepines, distinguished by the suffix "-zolam".

This product is intended for research and forensic applications. Warning - this product is not for human or veterinary use.

Pharmacology
Thienodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of etizolam on the nervous system.

Etizolam

Etizolam is a benzodiazepine-like drug that provides sedation, euphoria, and anxiety-reduction. It has been used medically in some regions for issues like anxiety, depression, insomnia, and panic disorder.

Etizolam first showed up on the online research concoction showcase in 2011. From that point forward its ubiquity has relentlessly expanded. This possible owes itself to the two its minimal effort and its wealth, and the exceptionally reliance shaping and addictive nature that it imparts to recreationally-utilized benzodiazepines.

Drug overview: Etizolam is a benzodiazepine analogue, a thienodiazepene1. It has gathered some popularity on the new psychoactive substance (NPS) market in the UK and Europe.

Chemical name(s): 4-(2-chlorophenyl)-2-ethyl-9-methyl-6Hthieno[3,2- f][1,2,4]triazolo[4,3-a][1,4]diazepine2.

Brand Names3: Etilaam, Etizest, Etizola, Sedekopan, Depas, Pasaden.

Classification: Depressant.

Background: Etizolam is unlicensed in the UK although used as a prescribed medication in other countries such as India4, Italy5 and Japan6. A 1mg tablet is equivalent to a 10mg diazepam (Valium) tablet7.

Etizolam isn't regularly endorsed and isn't perceived as a controlled substance in numerous parts of the world. It has been sold as an examination synthetic substitute for pharmaceutical benzodiazepines like alprazolam (Xanax) or diazepam (Valium). Etizolam is normally found in pellet or pill shape, laid on blotting surface paper, or as an unadulterated powder.

Outstanding impacts incorporate uneasiness concealment, disinhibition, muscle unwinding, sedation, and rapture. Etizolam is ordinarily controlled orally and sublingually because of the high bioavailability of these courses. Recounted reports recommend that as far as its relative strength, 1 mg of etizolam is roughly equal to 0.5 mg of alprazolam (Xanax), 0.5 mg of clonazepam (Klonopin), or 10 mg of diazepam (Valium). Usually contrasted with a less strong and calming form of alprazolam as far as the speed of its beginning, add up to term, and recreational impact.

Chemistry

Etizolam is a structural relative of benzodiazepines, whereby the benzene ring has been replaced by a thiophene ring, classifying it as a thienodiazepine. Thiophene is a five membered aromatic ring with one sulfur atom. Etizolam contains a thiophene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. This forms the thienodiazepine core of etizolam. An ethyl chain is bound to this bicyclic structure at R7. Additionally, a R2' chlorine-substituted phenyl ring is bound to this structure at R5.

Pharmacology

Thienodiazepines create an assortment of impacts by official to the benzodiazepine receptor site and amplifying the effectiveness and impacts of the neurotransmitter gamma aminobutyric corrosive (GABA) by following up on its receptors.[5] As this site is the most productive inhibitory receptor set inside the mind, its tweak results in the steadying (or quieting impacts) of etizolam on the sensory system.

Etizolam is for the most part expended orally, by gulping tablets or powder put into gel cases. It can likewise be taken sublingually (under the tongue). There are reports of grunting and rectal organization in spite of the fact that this has all the earmarks of being uncommon on the UK scene.

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